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논문 기본 정보

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학술저널
저자정보
Chi, Hee-Jun (ART Research Center) Chung, Da-Yeon (ART Research Center) Choi, Soon-Young (ART Research Center) Kim, Jong-Hyun (Department of Urology, Mizmedi Hospital) Kim, Gi-Young (Department of Urology, Mizmedi Hospital) Lee, Jae-Seok (Department of Urology, Mizmedi Hospital) Lee, Hee-Sun (Department of Obstetrics and Gynecology, Mizmedi Hospital) Kim, Myung-Hee (Department of Obstetrics and Gynecology, Mizmedi Hospital) Roh, Sung-Il (Department of Obstetrics and Gynecology, Mizmedi Hospital)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제38권 제1호
발행연도
2011.1
수록면
10 - 17 (8page)

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Objective: To explore potential relationships between sperm DNA integrity and both semen parameters and clinical outcomes. Methods: Semen analysis of 498 samples was performed according to the 2010 criteria of the World Health Organization. The sperm DNA fragmentation Index (DFI) of the semen samples was assessed using a neutral comet assay. Results: Sperm DFI showed a significant correlation with semen parameters, including the patient's age, sperm viability, motility, morphology, and number of leukocytes (p<0.05). The sperm DFI values for asthenozoospermic (15.2%), oligoteratozoospermic (18.3%), asthenoteratozoospermic (17.5%), and oligoasthenoteratozoospermic semen samples (21.3%) were significantly higher than that observed in normozoospermic semen samples (10.5%, p<0.05). A sperm DFI value of 14% was used as a threshold of sperm DFI in assessing whether DNA was highly damaged. In 114 IVF-ET cycles, the fertilization rate of the sperm DFI <14% group (70 cycles, 61.7%) was significantly higher than that observed for the ${\geq}14%$ group (44 cycles, 55.3%), but there was no difference in the other clinical outcomes between the two groups. In the ${\geq}14%$ group, the pregnancy rates of the ICSI cycles (40.0%) and half-ICSI (44.0%) were higher than conventional IVF cycles (30.7%), but the difference was not statistically significant. Conclusion: Along with the conventional semen analysis, the sperm DFI assessed using the comet assay was shown to improve the quality of the semen evaluation. To evaluate the precise effect of ICSI on pregnancy rates in the patients who demonstrate high sperm DFI values, further study is necessary.
#Spermatozoa #Comet Assay #Semen Analysis #Clinical Outcome #Human

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참고문헌 (41)

참고문헌 신청
Nasr-Esfahani MH / 2005 / Effect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI / Reprod Biomed Online 11:198~205 google schola Sakkas D / 1999 / Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway / Exp Cell Res 251:350~355 google schola Aitken RJ / 2001 / Oxidative stress, DNA damage and the Y chromosome / Reproduction 122:497~506 google schola Lo KC / 2004 / The testis and male accessory organs, in Yen and Jaffe’s reproductive endocrinology: physiology, endocrinology, and clinical management. 5th ed. / Elsevier Saunders :367~387 google schola Lewis SE / 2008 / Using the alkaline comet assay in prognostic tests for male infertility and assisted reproductive technology outcomes / Mutagenesis 23:163~170 google schola

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