지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 84 - 88 (5page)
이용수
초록· 키워드
오류제보하기
Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and can result in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenous immunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalence in recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KD remains unclear, there has been increasing evidence for the role of genetic susceptibility to the disease since it was discovered in 1967. We retrospectively reviewed previous genetic research for known susceptibility genes in the pathogenesis of KD, IVIG resistance, and the development of CAL. This review revealed numerous potential susceptibility genes including genetic polymorphisms of ITPKC, CASP3, the transforming growth factor-${\beta}$ signaling pathway, B lymphoid tyrosine kinase, FCGR2A, KCNN2, and other genes, an imbalance of Th17/Treg, and a range of suggested future treatment options. The results of genetic research may improve our understanding of the pathogenesis of KD, and aid in the discovery of new treatment modalities for high-risk patients with KD.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Recent Advances in Kawasaki Disease
Yonsei Medical Journal
2016 .01
-
Reality of Kawasaki disease epidemiology
Clinical and Experimental Pediatrics
2019 .01
-
Understanding the importance of cerebrovascular involvement in Kawasaki disease
Clinical and Experimental Pediatrics
2019 .01
-
Assessment of the clinical heterogeneity of Kawasaki disease using genetic variants of BLK and FCGR2A
Korean Circulation Journal
2019 .01
-
Factors Predicting Resistance to Intravenous Immunoglobulin Treatment and Coronary Artery Lesion in Patients with Kawasaki Disease: Analysis of the Korean Nationwide Multicenter Survey from 2012 to 2014
Korean Circulation Journal
2018 .01
-
Sex-Specific Susceptibility Loci Associated With Coronary Artery Aneurysms in Patients With Kawasaki Disease
Korean Circulation Journal
2024 .09
-
Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
Clinical and Experimental Pediatrics
2018 .01
-
Clinical Characteristics of Kawasaki Disease in Infants Younger than Six Months: A Single-Center Study
Korean Circulation Journal
2016 .01
-
Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease
Childhood Kidney Diseases
2015 .01
-
Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease
Clinical and Experimental Pediatrics
2019 .01
-
천식과 가와사키병의 연관성
Allergy Asthma & Respiratory Diseases
2019 .01
-
Significance of Differential Characteristics in Infantile Kawasaki Disease
Korean Circulation Journal
2019 .01
-
Differentiation between incomplete Kawasaki disease and secondary hemophagocytic lymphohistiocytosis following Kawasaki disease using N-terminal pro-brain natriuretic peptide
Clinical and Experimental Pediatrics
2018 .01
-
Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease
Yonsei Medical Journal
2018 .01
-
Changes in the Clinical Characteristics of Kawasaki Disease After Coronavirus Disease (COVID-19) Pandemic: A Database Analysis
Journal of Korean Medical Science
2022 .05
-
국내 가와사키병 환아의 약물사용
한국임상약학회지
2017 .01
-
Clinical outcome of patients with refractory Kawasaki disease based on treatment modalities
Clinical and Experimental Pediatrics
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0