Zinc and Zinc Related Enzymes in Precancerous and Cancerous Tissue in the Colon of Dimethyl Hydrazine Treated Rats

Christudoss, Pamela; Selvakumar, R.; Pulimood, Anna B.; Fleming, Jude Joseph; Mathew, George

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자료유형: 학술저널

저자정보: Christudoss, Pamela (Department of Clinical Biochemistry, Christian Medical College) Selvakumar, R. (Department of Clinical Biochemistry, Christian Medical College) Pulimood, Anna B. (Department of Gi Sciences, Christian Medical College) Fleming, Jude Joseph (Department of Clinical Biochemistry, Christian Medical College) Mathew, George (Department of General Surgery, Christian Medical College)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제2호

발행연도: 2012.1

수록면: 487 - 492 (6page)

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Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

#Colon cancer #zinc #DMH #CuZnSOD #alkaline phosphatase #precancerous

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