Influence of Alcohol Consumption on Oxidative Stress and Antioxidant Status in Cancer Patients - Case-control Study from Western Nepal

Nagamma, T.; Bhutia, Rinchen Doma; Pokharel, Daya Ram; Yadav, Saraswati; Baxi, J.

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자료유형: 학술저널

저자정보: Nagamma, T. (Department of biochemistry, Melaka Manipal Medical College) Bhutia, Rinchen Doma (Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences) Pokharel, Daya Ram (Department of Physiology, Narayana Medical College) Yadav, Saraswati (Department of biochemistry, Manipal College of Medical Sciences) Baxi, J. (Department of Surgery, Manipal College of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제7호

발행연도: 2012.1

수록면: 3,513 - 3,517 (5page)

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Aim: The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer. Methods: This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, ${\alpha}$-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared. Results: The TBARS level was found to be significantly higher ($p{\leq}0.001$) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance ($p{\geq}0.05$) was observed in the level of vitamin C and ${\alpha}$-tocopherol. GSH and TAA level were significantly decreased ($p{\leq}0.001$) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit. Conclusion: Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.

#Alcohol #oxidative stress #antioxidants #cancer #Western Nepal

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