Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis

Wang, Ying; Qu, Xiao; Shen, Hong-Chang; Wang, Kai; Liu, Qi; Du, Jia-Jun

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자료유형: 학술저널

저자정보: Wang, Ying (Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University) Qu, Xiao (Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University) Shen, Hong-Chang (Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University) Wang, Kai (Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University) Liu, Qi (Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University) Du, Jia-Jun (Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제11호

발행연도: 2015.1

수록면: 4,759 - 4,768 (10page)

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Background: Several studies have investigated predictive and prognostic biomarkers for patients treated with anti-epidermal growth factor receptor (EGFR) agents in lung cancer. However, the conclusion is controversial. Materials and Methods: A meta-analysis was conducted to evaluate the associations of mutant K-ras, PIK3CA and PTEN deficiency with the efficacy of anti-EGFR agents in lung cancer. The primary endpoint was objective response rate (ORR). The secondary endpoints were overall survival (OS) and progression-free survival (PFS). Results: A total of 61 studies were included in the final meta-analysis. The result showed that K-ras mutation was a good predictor for ORR (RR=0.42, 95%CI, 0.33-0.55, p=0.000) and an effective prognostic marker for OS (HR=1.37, 95%CI, 1.15-1.65, p=0.001) and PFS (HR=1.33, 95%CI, 1.05-1.69, p=0.019). However, PTEN deficiency or PIK3CA mutation did not show any significance predictive value for ORR (PTEN, RR=0.82, 95%CI, 0.56-1.19, p=0.286; PIK3CA, RR=1.08, 95%CI, 0.17-6.66, P=0.938). And PTEN deficiency or expression of PIK3CA did not show significance prognostic value for OS (PTEN, HR=0.88, 95%CI, 0.31-2.46,P=0.805; PIK3CA, HR=0.79, 95%CI: 0.23-2.68, P=0.706). Conclusions: Our meta-analysis showed that K-ras mutation may be an effective predictor in lung cancer patients treated with anti-EGFR agents. Whereas, the predictive and prognostic value of PTEN deficiency and PIK3CA mutation need to be further investigated.

#Hung cancer #K-ras mutation #loss of PTEN #PIK3CA mutation #anti-EGFR agents

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