hOGG1, p53 Genes, and Smoking Interactions are Associated with the Development of Lung Cancer

Cheng, Zhe; Wang, Wei; Song, Yong-Na; Kang, Yan; Xia, Jie

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저자정보: Cheng, Zhe (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) Wang, Wei (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) Song, Yong-Na (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) Kang, Yan (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities) Xia, Jie (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 1,803 - 1,808 (6page)

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This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphism in p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. At the same time, smoking status was investigated between the two groups. Logistic regression was used to estimate the effects of Ser/Cys polymorphism and Arg/Pro polymorphisms, smoking and their interactions on the development of lung cancer. ORs (95% CI) of smoking, hOGG1 Cys/Cys and p53 Pro/Pro genotypes were 2.34 (1.41-3.88), 2.12 (1.03-4.39), and 2.12 (1.15-3.94), respectively. The interaction model of smoking and Cys/Cys was super-multiplicative or multiplicative, and the OR (95% CI) for their interaction item was 1.67 (0.36 -7.78). The interaction model of smoking and Pro/Pro was super-multiplicative with an OR (95%CI) of their interaction item of 5.03 (1.26-20.1). The interaction model of Pro/Pro and Cys/Cys was multiplicative and the OR (95%CI) of their interaction item was 0.99 (0.19-5.28). Smoking, hOGG1 Cys/Cys, p53 Pro/Pro and their interactions may be the important factors leading to the development of lung cancer.

#hOGG1 gene #lung cancer #smoking #gene polymorphism #genetic susceptibility

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Cheng, Zhe

소속기관 Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute