Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma

Kang, Ji Young; Kim, In Kyoung; Hur, Jung; Kim, Seok Chan; Lee, Sook Young; Kwon, Soon Seog; Kim, Young Kyoon

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자료유형: 학술저널

저자정보: Kang, Ji Young (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Kim, In Kyoung (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Hur, Jung (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Kim, Seok Chan (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Lee, Sook Young (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Kwon, Soon Seog (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) Kim, Young Kyoon (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)

저널정보: 대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제82권 제1호

발행연도: 2019.1

수록면: 71 - 80 (10page)

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Background: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly has not been clearly verified. The objective of this study was to investigate the effect of tiotropium and expression of muscarinic receptors as its related mechanism in an aged mouse model of chronic asthma with airway remodeling. Methods: BALB/c female mice age 6 weeks, 9 and 15 months were sensitized and challenged with ovalbumin (OVA) for three months. Tiotropium bromide was administered during the challenge period. Airway hyperresponsiveness (AHR) and pulmonary inflammation were measured. Parameters of airway remodeling, and expression levels of $M_2$ and $M_3$ receptors were examined. Results: Total cell with eosinophils, increased in the OVA groups by age, was decreased significantly after treatment with tiotropium bromide, particularly in the age group of 15 months. AHR and levels of interleukin (IL)-4, IL-5, and IL-13 were decreased, after tiotropium administration. In old aged group of 9- and 15-months-treated groups, hydroxyproline contents and levels of ${\alpha}$-smooth muscle actin were attenuated. Tiotropium enhanced the expression of $M_2$ but decreased expression of $M_3$ in all aged groups of OVA. Conclusion: Tiotropium bromide had anti-inflammatory and anti-remodeling effects in an aged mouse model of chronic asthma. Its effects seemed to be partly mediated by modulating expression $M_3$ and $M_2$ muscarinic receptors. Tiotropium may be a beneficial treatment option for the elderly with airway remodeling of chronic asthma.

#Receptors, Muscarinic #Ageing #Asthma #Tiotropium Bromide #Airway Remodeling

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