Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

Arvas, Macit; Salihoglu, Yavuz; Sal, Veysel; Gungor, Tayfun; Sozen, Hamdullah; Kahramanoglu, Ilker; Topuz, Samet; Demirkiran, Fuat; Iyibozkurt, Cem; Bese, Tugan; Ozgu, Burcin Salman; Vatansever, Dogan; Tokgozoglu, Nedim; Berkman, Sinan; Turan, Hasan; Bengisu, Ergin; Sofiyeva, Nigar; Demiral, Irem; Meydanli, Mutlu

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자료유형: 학술저널

저자정보: Arvas, Macit (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Faculty of Medicine, Istanbul University) Salihoglu, Yavuz (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Istanbul Faculty of Medicine, Istanbul University) Sal, Veysel (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Faculty of Medicine, Istanbul University) Gungor, Tayfun (Dr Zekai Tahir Burak Womens Health Research and Education Hospital) Sozen, Hamdullah (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Istanbul Faculty of Medicine, Istanbul University) Kahramanoglu, Ilker (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Faculty of Medicine, Istanbul University) Topuz, Samet (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Istanbul Faculty of Medicine, Istanbul University) Demirkiran, Fuat (Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Faculty of Medicine, Istanbul University) Iyibozkurt, Cem (Department of Obstetrics and Gynec) Bese, Tugan Ozgu, Burcin Salman Vatansever, Dogan Tokgozoglu, Nedim Berkman, Sinan Turan, Hasan Bengisu, Ergin Sofiyeva, Nigar Demiral, Irem Meydanli, Mutlu

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제4호

발행연도: 2016.1

수록면: 1,909 - 1,915 (7page)

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Background: The purpose of this study was to determine the benefit of tertiary cytoreductive surgery (TC) for secondary recurrent epithelial ovarian cancer (EOC), focusing on whether optimal cytoreduction has an impact on disease-free survival, and whether certain patient characteristics could identify ideal candidates for TC. Materials and Methods: Retrospective analysis of secondary recurrent EOC patients undergoing TC at three Turkish tertiary institutions from May 1997 to July 2014 was performed. All patients had previously received primary cytoreduction followed by intravenous platinum-based chemotherapy and secondary cytoreduction for first recurrence. Clinical and pathological data were obtained from the patients' medical records. Survival analysis was caried out using the Kaplan Meier method. Actuarial curves were compared by the two tailed Logrank test with a statistical significance level of 0.05. Results: Median age of the patients was 49.6 years (range, 30-67) and thirty-eight (72%) had stage III-IV disease at initial diagnosis. Twenty six (49%) had optimal and 27 (51%) suboptimal cytoreduction during tertiary debulking surgery. Optimal initial cytoreduction, time to first recurrence, optimal secondary cytoreduction, time interval between secondary cytoreduction and secondary recurrence, size of recurrence, disease status at last follow-up were found to be significant risk factors to predict optimal TC. Optimal cytoreduction in initial and tertiary surgery and serum CA-125 level prior to TC were independent prognostic factors on univariate analysis. Conclusions: Our results and a literature review clearly showed that maximal surgical effort should be made in TC, since patients undergoing optimal TC have a better survival. Thus, patients with secondary recurrent EOC in whom optimal cytoreduction can be achieved should be actively selected.

#Ovarian cancer #recurrence #cytoreduction #surgery #survival

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Arvas, Macit

소속기관 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cerrahpasa Faculty of Med