The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

Jiang, Yuan; Hou, Jing; Zhang, Qiang; Jia, Shu-Ting; Wang, Bo-Yuan; Zhang, Ji-Hong; Tang, Wen-Ru; Luo, Ying

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자료유형: 학술저널

저자정보: Jiang, Yuan (Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology) Hou, Jing (Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology) Zhang, Qiang (Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology) Jia, Shu-Ting (Lab of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology) Wang, Bo-Yuan (Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology & Faculty of Environmental Science and Engineering, Kunming University of Science and Technolog) Zhang, Ji-Hong (Lab of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology) Tang, Wen-Ru (Lab of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology) Luo, Ying (Lab of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Techno)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제11호

발행연도: 2013.1

수록면: 6,357 - 6,362 (6page)

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Background: The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) has been associated with acute lymphoblastic leukemia (ALL). However, results were conflicting. The aim of this study was to quantitatively summarize the evidence for the MTHFRC677T polymorphism and ALL risk. Methods: Electronic searches of PubMed and the Chinese Biomedicine database were conducted to select case-control studies containing available genotype frequencies of C677T and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of any association. Results: Case-control studies including 6,371 cases and 10,850 controls were identified. The meta-analysis stratified by ethnicity showed that individuals with the homozygous TT genotype had decreased risk of ALL (OR= 0.776, 95% CI: 0.687~0.877, p< 0.001) in Caucasians (OR= 0.715, 95% CI: 0.655~0.781, p= 0.000). However, results among Asians (OR=0.711, 95% CI: 0.591~1.005, p= 0.055) and others (OR=0.913, 95% CI: 0.656~1.271, p= 0. 590) did not suggest an association. A symmetric funnel plot, the Egger's test (P=0.093), and the Begg- test (P=0.072) were all suggestive of the lack of publication bias. Conclusion: This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between the MTHFRC677T polymorphism and ALL.

#MTHFR C677T #meta-analysis #acute lymphoblastic leukemia #risk factor

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