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논문 기본 정보

자료유형
학술저널
저자정보
Chen, Yan-Jie (Department of Gastroenterology, Zhongshan Hospital of Fudan University) Ma, Yu-Shui (Department of Gastroenterology, Zhongshan Hospital of Fudan University) Fang, Ying (Department of Gastroenterology, Zhongshan Hospital of Fudan University) Wang, Yi (Department of Gastroenterology, Zhongshan Hospital of Fudan University) Fu, Da (Department of Gastroenterology, Zhongshan Hospital of Fudan University) Shen, Xi-Zhong (Department of Gastroenterology, Zhongshan Hospital of Fudan University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제4호
발행연도
2013.1
수록면
2,173 - 2,179 (7page)

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Ubiquitin carboxyl-terminal hydrolase 37 (UCH37, also called UCHL5), a member of the deubiquitinating enzymes, can suppress protein degradation through disassembling polyubiquitin from the distal subunit of the chain. It has been proved that UCH37 can be activated by proteasome ubiqutin chain receptor Rpn13 and incorporation into the 19S complex. UCH37, which has been reported to assist in the mental development of mice, may play an important role in oncogenesis, tumor invasion and migration. Further studies will allow a better understanding of roles in cell physiology and pathology, embryonic development and tumor formation, hopefully providing support for the idea that UCH37 may constitute a new interesting target for the development of anticancer drugs.

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