Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Zhu, Wen-Jiang; Huang, Chu-Ying; Li, Chuan; Peng, Wei; Wen, Tian-Fu; Yan, Lv-Nan; Li, Bo; Wang, Wen-Tao; Xu, Ming-Qing; Yang, Jia-Yin; Jiang, Li

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자료유형: 학술저널

저자정보: Zhu, Wen-Jiang (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Huang, Chu-Ying (Department of Medical Oncology, West China Hospital of Sichuan University) Li, Chuan (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Peng, Wei (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Wen, Tian-Fu (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Yan, Lv-Nan (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Li, Bo (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Wang, Wen-Tao (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Xu, Ming-Qing (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Yang, Jia-Yin (Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University) Jiang, Li

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호

발행연도: 2013.1

수록면: 7,101 - 7,106 (6page)

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Background: The prognosis of patients with hepatocellular carcinoma (HCC) after curative resection varies greatly. Few studies had investigated the risk factors for early recurrence (recurrence-free time ${\leq}$ 1 year) of hepatitis B virus (HBV)-related HCCs meeting Milan criteria. Methods: A retrospective analysis was performed on the 224 patients with HCC meeting Milan criteria who underwent curative liver resection in our center between February 2007 and March 2012. The overall survival (OS) rate, recurrence-free survival (RFS) rate and risk factors for early recurrence were analyzed. Results: After a median follow-up of 33.3 months, HCC reoccurred in 105 of 224 patients and 32 died during the period. The 1-, 3- and 5-year OS rates were 97.3%, 81.6% and 75.6% respectively, and the 1-, 3- and 5-year RFS rates were 73.2%, 53.7% and 41.6%. Cox regression showed alpha-fetoprotein (AFP) > 800 ng/ml (HR 2.538, 95% CI 1.464-4.401, P=0.001), multiple tumors (HR 2.286, 95% CI 1.123-4.246, P=0.009) and microvascular invasion (HR 2.518, 95% CI 1.475-4.298, P=0.001) to be associated with early recurrence (recurrence-free time ${\leq}$ 1-year) of HCC meeting Milan criteria. Conclusions: AFP > 800 ng/ml, multiple tumors and microvascular invasion are independent risk factors affecting early postoperative recurrence of HCC. In addition resection appears capable of replacing liver transplantation in some situations with safety and a better outcome.

#Hepatocellular carcinoma #Milan criteria #early recurrence #factors #curative resection

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