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논문 기본 정보

자료유형
학술저널
저자정보
Li, Feng-Ying (Clinical Laboratory, Sir Run Run Shaw Hospital, Medical School of Zhejiang University) Ren, Xiao-Bin (Hangzhou Municipal Center for Disease Control and Prevention) Xie, Xin-You (Clinical Laboratory, Sir Run Run Shaw Hospital, Medical School of Zhejiang University) Zhang, Jun (Clinical Laboratory, Sir Run Run Shaw Hospital, Medical School of Zhejiang University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호
발행연도
2013.1
수록면
7,203 - 7,206 (4page)

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Recent studies suggested that the ovarian cancers with negative excision repair cross-complementation group 1 enzyme (ERCC1) expression have a better response to platinum-based chemotherapy than those with positive ERCC1 expression. The objective of this study was to evaluate whether ERCC1 expression is associated with response to platinum-based chemotherapy in ovarian cancers. MEDLINE, PubMed, Web of Science and CNKI databases were used for searching studies relating to ERCC1 protein expression and response to platinum-based chemotherapy in ovarian cancers. Statistical analysis was based on the method for a fixed effects meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals for ERCC1 protein expression and response to platinum-based chemotherapy were generated. Publication bias was investigated with Begg's test. Five studies involving 306 patients with ovarian cancer were included. Compared to patients with positive ERCC1 expression, those with negative ERCC1 expression had a better response to platinum-based chemotherapy. The pooled OR was 5.264 (95% CI: 2.928-9.464, P < 0.001) and publication bias was not found (P = 0.904). The result was similar in both in Asians and Caucasians (P < 0.001 and P = 0.028, respectively). ERCC1 protein expression status is significantly associated with response to platinum-based chemotherapy in ovarian cancers.

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