Diagnostic Value of F-FDG PET/CT in Comparison to Bone Scintigraphy, CT and F-FDG PET for the Detection of Bone Metastasis

Liu, Ning-Bo; Zhu, Lei; Li, Ming-Huan; Sun, Xiao-Rong; Hu, Man; Huo, Zong-Wei; Xu, Wen-Gui; Yu, Jin-Ming

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자료유형: 학술저널

저자정보: Liu, Ning-Bo (Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital) Zhu, Lei (Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital) Li, Ming-Huan (Department of Radiation Oncology, Shandong Cancer Hospital) Sun, Xiao-Rong (Department of Nuclear Medicine, Shandong Cancer Hospital) Hu, Man (Department of Radiation Oncology, Shandong Cancer Hospital) Huo, Zong-Wei (PET/CT Center of Shandong Cancer Hospital) Xu, Wen-Gui (Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital) Yu, Jin-Ming (Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,647 - 3,652 (6page)

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Purpose: To evaluate the diagnostic value of $^{18}F$-FDG PET/CT for detection of bone metastasis in comparison with the efficacies of $^{18}F$-FDG PET/CT, CT, $^{18}F$-FDG PET and conventional planar bone scintigraphy in a series of cancer patients. Methods: Five hundred and thirty patients who underwent both $^{18}F$-FDG PET/CT and bone scintigraphy within 1 month were retrospectively analyzed. The skeletal system was classified into 10 anatomic segments and interpreted blindly and separately. For each modality, the sensitivity, specificity, accuracy, PPV and NPV were calculated and the results were statistically analyzed. Results: Bone metastases were confirmed in 117 patients with 459 positive segments. On patient-based analysis, the sensitivity, specificity, accuracy, PPV and NPV of $^{18}F$-FDG PET/CT were significantly higher than bone scintigraphy, CT and $^{18}F$-FDG PET (P<0.05). On segment-based analysis, the sensitivity of CT, bone scintigraphy, $^{18}F$-FDG PET and $^{18}F$-FDG PET/CT were 70.4%, 89.5%, 89.1% and 97.8%, respectively (P<0.05, compared with $^{18}F$-FDG PET/CT). The overall specificity and accuracy of the four modalities were 89.1%, 91.8%, 90.3%, 98.2% and 90.3%, 90.9%, 89.8%, 98.0%, respectively (P<0.05, compared with $^{18}F$-FDG PET/CT). The PPV and NPV were 89.8%, 87.6%, 85.6%, 97.2% and 85.6%, 93.2%, 92.8%, 98.6%, respectively. Three hundred and twelve lesions or segments were presented as lytic or sclerotic changes on CT images at the corresponding sites of increased $^{18}F$-FDG uptake. In lytic or mixed lesions, the sensitivity of $^{18}F$-FDG PET/CT and $^{18}F$-FDG PET were better than bone scintigraphy, while in osteoblastic lesions bone scintigraphy had a similar performance with $^{18}F$-FDG PET/CT but better than $^{18}F$-FDG PET alone. Conclusion: Our data allow the conclusion that $^{18}F$-FDG PET/CT is superior to planar bone scintigraphy, CT or $^{18}F$-FDG PET in detecting bone metastasis. $^{18}F$-FDG PET/CT may enhance our diagnosis of tumor bone metastasis and provide more information for cancer treatment.

#$^{18}F$-FDG #PET-CT #bone scintigraphy #CT #bone metastasis

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Liu, Ning-Bo

소속기관 Department of Radiation Oncology and Key Laboratory of Cancer Prevention and Therapy, Tianjin Medica