Clinicopathological Characteristics and Prognosis of Patients According to Recurrence Time After Curative Resection for Colorectal Cancer

Bozkurt, Oktay; Inanc, Mevlude; Turkmen, Esma; Karaca, Halit; Berk, Veli; Duran, Ayse Ocak; Ozaslan, Ersin; Ucar, Mahmut; Hacibekiroglu, Ilhan; Eker, Baki; Baspinar, Osman; Ozkan, Metin

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자료유형: 학술저널

저자정보: Bozkurt, Oktay (Department of Medical Oncology, Erciyes University Faculty of Medicine) Inanc, Mevlude (Medical Oncology Department, Kayseri Training and Research Hospital) Turkmen, Esma (Department of Medical Oncology, Trakya University Faculty of Medicine) Karaca, Halit (Department of Medical Oncology, Erciyes University Faculty of Medicine) Berk, Veli (Department of Medical Oncology, Erciyes University Faculty of Medicine) Duran, Ayse Ocak (Department of Medical Oncology, Erciyes University Faculty of Medicine) Ozaslan, Ersin (Department of Medical Oncology, Erciyes University Faculty of Medicine) Ucar, Mahmut (Department of Medical Oncology, Erciyes University Faculty of Medicine) Hacibekiroglu, Ilhan (Department of Medical Oncology, Trakya University Faculty of Medicine) Eker, Baki (Internal Medicine Department, Kayseri Training and Research Hospital) Baspinar, Osman (Internal Medicine Department, Kayseri Training and Research Hospital) Ozkan, Metin (Department of Medical Oncology, Erciyes University Faculty of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제21호

발행연도: 2014.1

수록면: 9,277 - 9,281 (5page)

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Purpose: To investigate clinicopathological features in patients with recurrent colorectal cancer within 1 year and more than 1 year after curative resection. Materials and Methods: We retrospectively evaluated 103 patients with disease recurrence before versus after 1 year of resection. Thirty-two patients (31%) were diagnosed with recurrence less than 1 year after curative resection for colorectal cancer (early recurrence) and 71 (69%) after more than 1 year (non-early recurrence). Results: The early recurrence group displayed a significantly lower overall survival rate for both colon cancer (p=0, 01) and rectal cancer (p<0.001). Inadequate lymph node dissection was a significant predictor for early relapse. There were no statistically significant differences in clinicopathological variables such as age, sex, primary tumor localization, stage, depth of invasion, lymphovascular invasion and perineural invasion between the early and non-early recurrence groups. However, a K-ras mutation subgroup was significantly associated with early recurrence (p<0.001). Conclusions: Poor survival is associated with early recurrence for patients undergoing resection for non-metastatic colorectal cancer, as well as K-ras mutation.

#Predictive and prognostic factors #early recurrence #colorectal cancer #K-ras

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