Differential Distribution of microRNAs in Breast Cancer Grouped by Clinicopathological Subtypes

Li, Jian-Yi; Jia, Shi; Zhang, Wen-Hai; Zhang, Yang; Kang, Ye; Li, Pi-Song

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자료유형: 학술저널

저자정보: Li, Jian-Yi (Department of Breast Surgery, Shengjing Hospital of China Medical University) Jia, Shi (Department of Breast Surgery, Shengjing Hospital of China Medical University) Zhang, Wen-Hai (Department of Breast Surgery, Shengjing Hospital of China Medical University) Zhang, Yang (Department of Breast Surgery, Shengjing Hospital of China Medical University) Kang, Ye (Department of Breast Surgery, Shengjing Hospital of China Medical University) Li, Pi-Song (Department of Breast Surgery, Shengjing Hospital of China Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 3,197 - 3,203 (7page)

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Background: microRNAs (miRNAs) that regulate proliferation, invasion and metastasis are considered to be the principal molecular basis of tumor heterogeneity. Breast cancer is not a homogeneous tissue. Thus, it is very important to perform microarray-based miRNA screening of tumors at different sites. Methods: Breast tissue samples from the centers and edges of tumors of 30 patients were classified into 5 clinicopathological subtypes. In each group, 6 specimens were examined by microRNA array. All differential miRNAs were analyzed between the edges and centers of the tumors. Results: Seventeen kinds of miRNAs were heterogeneously distributed in the tumors from different clinicopathological subtypes that included 1 kind of miRNA in Luminal A and Luminal B Her2+ subtypes, 4 kinds in Luminal A and Her2 overexpression subtypes, 6 kinds in Luminal B Ki67+ and Luminal B Her2+ subtypes, 2 kinds between Luminal B Ki67+ and triple-negative breast cancer (TNBC) subtypes, 2 kinds between Luminal B Her2+ and TNBC subtypes, and 2 kinds between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes. Twenty kinds of miRNAs were homogenously distributed in the tumors from different clinicopathological subtypes that included 6 kinds of miRNAs in Luminal B Ki67+ and Luminal B Her2+ subtypes, 1 kind in Luminal B Ki67+ and Her2 overexpression subtypes, 10 kinds between Luminal B Ki67+ and TNBC subtypes, 2 kinds in Luminal B Her2+ and TNBC subtypes, and 1 kind between Luminal B Ki67+, Luminal B Her2+, and TNBC subtypes. Conclusions: A total of 37 miRNAs were significantly distributed in tumors from the centers to edges, and in all clinicopathological subtypes.

#microRNA #breast cancer #clinicopathological subtype #heterogeneity

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