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학술저널
저자정보
Mirinezhad, Seyed Kazem (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) Somi, Mohammad Hossein (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) Shirmohamadi, Masoud (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) Seyednejad, Farshad (Radiation Oncology Therapy of IMAM REZA [AS] Hospital, Tabriz University of Medical Sciences) Jangjoo, Amir Ghasemi (Radiation Oncology Therapy of IMAM REZA [AS] Hospital, Tabriz University of Medical Sciences) Ghojazadeh, Morteza (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) Mohammadzadeh, Mohammad (Radiation Oncology Therapy of IMAM REZA [AS] Hospital, Tabriz University of Medical Sciences) Naseri, Ali Reza (Radiation Oncology Therapy of IMAM REZA [AS] Hospital, Tabriz University of Medical Sciences) Nasiri, Behnam (Radiation Oncology Therapy of IMAM REZA [AS] Hospital, Tabriz University of Medical Sciences)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호
발행연도
2013.1
수록면
3,921 - 3,924 (4page)

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Background: To investigate the role of surgical treatment for locally advanced esophageal cancer, we compared the outcomes of chemoradiotheroy alone (CRT) to postoperative chemoradiotherapy (S/CRT), using, Regional Radiotherapy Center, database. Materials and Methods: This retrospective study was conducted in North-West of Iran, included of 255 consecutive patients with esophageal cancer. Eligible operable and non-operable, were treated with S/CRT and CRT respectively. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutive days in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. Results: From March 2006 to March 2011 255 patients: male/female 129/96, median age 68 (35-90), squamous/adeno 213/12, received CRT/S+CRT 166/59, median radiation dose $45{\pm}13.6Gy$, Median survival 13.5 (11-15), overall survival (OS) One/Two/Three 57/21/16%, Died/alive 158/97, Univariate analysis prognostic factors: age/stag/differentiation/dose of RT/fraction/treatment, Multivariate analysis predictor factor: dose of RT/fraction. Conclusions: Although this treatment offers some possibility for improvement of patients with esophageal cancer, there remains a significant need for development of new drug and new therapeutic approaches that can substantially impact survival.

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