Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

Deng, Qi-Wen; He, Bang-Shun; Pan, Yu-Qin; Sun, Hui-Ling; Xu, Ye-Qiong; Gao, Tian-Yi; Li, Rui; Song, Guo-Qi; Wang, Shu-Kui

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자료유형: 학술저널

저자정보: Deng, Qi-Wen (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) He, Bang-Shun (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) Pan, Yu-Qin (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) Sun, Hui-Ling (Department of Life Sciences, Nanjing Normal University) Xu, Ye-Qiong (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) Gao, Tian-Yi (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) Li, Rui (Department of Life Sciences, Nanjing Normal University) Song, Guo-Qi (Central Laboratory, Nanjing First Hospital, Nanjing Medical University) Wang, Shu-Kui (Central Laboratory, Nanjing First Hospital, Nanjing Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호

발행연도: 2014.1

수록면: 3,705 - 3,713 (9page)

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E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.

#E-cadherin #CDH1) polymorphism #invasion #metastasis #cancer risk #meta-analysis

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