No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Ahangar-Oskouee, Mahin; Shahmahmoodi, Shohreh; Jalilvand, Somayeh; Mahmoodi, Mahmood; Ziaee, Abed Ali; Esmaeili, Heidar-Ali; Keshtvarz, Maryam; Pishraft-Sabet, Leila; Yousefi, Maryam; Mollaei-Kandelous, Yaghoob; Mokhtari-Azad, Talat; Nategh, Rakhshandeh

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자료유형: 학술저널

저자정보: Ahangar-Oskouee, Mahin (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Shahmahmoodi, Shohreh (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Jalilvand, Somayeh (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Mahmoodi, Mahmood (Department of Statistics, School of Public Health, Tehran University of Medical Sciences) Ziaee, Abed Ali (Institute of Biochemistry and Biophysics, Tehran University) Esmaeili, Heidar-Ali (Department of Pathobiology, Tabriz University of Medical Sciences) Keshtvarz, Maryam (Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences) Pishraft-Sabet, Leila (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Yousefi, Maryam (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Mollaei-Kandelous, Yaghoob (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Mokhtari-Azad, Talat (Department of Virology, School of Public Health, Tehran University of Medical Sciences) Nategh, Rakhshandeh (Department of Virology, School of Public Health, Tehran Univers)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 4,061 - 4,065 (5page)

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The presence of viral DNA in breast cancer cells is controversial. However, some studies have revealed a possible role for the human papillomavirus in the pathogenesis of breast cancer. The aim of the present study was to investigate the presence of HPV-DNA in breast tissue in a group of Iranian women with and without breast cancer and identification of the detected HPV types. Paraffin-embedded specimens from 65 malignant breast cancer cases and 65 cases with benign breast lesions were investigated for presence of HPV-DNA by nested polymerase chain reaction. We found HPV-DNA in 22 (33.8%) of the breast cancer specimens. All non-cancerous specimens were negative. Low and high-risk HPV types, including HPV-6 (26.2%), HPV-16 (1.5%), HPV-35 (1.5%), HPV-52 (1.5%), and HPV-11 (1.5%) were detected in our study. HPV-6 was the most prevalent type in the breast cancer specimens. Although high-risk HPV types have been shown to have a major role in cervix cancer, there have been no data that support the same relevance for other types of malignancies. Furthermore, presence of low-risk HPV types in malignancies still is a matter of debate. The data presented in this study indicates a strong need for epidemiological studies correlating different HPV types in human breast cancer.

#Human papillomavirus #breast cancer #Iran

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