Overexpression of NDRG2 Can Inhibit Neuroblastoma Cell Proliferation through Negative Regulation by CYR61

Zhang, Zhi-Guo; Li, Gang; Feng, Da-Yun; Zhang, Jian; Zhang, Jing; Qin, Huai-Zhou; Ma, Lian-Ting; Gao, Guo-Dong; Wu, Lin

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자료유형: 학술저널

저자정보: Zhang, Zhi-Guo (Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital) Li, Gang (Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital) Feng, Da-Yun (Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital) Zhang, Jian (Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, the Fourth Military Medical University) Zhang, Jing (Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, the Fourth Military Medical University) Qin, Huai-Zhou (Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital) Ma, Lian-Ting (Postdoctoral Research Station of Neurosurgery, Wuhan General Hospital of Guangzhou Command, PLA) Gao, Guo-Dong (Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital) Wu, Lin (Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, the Fourth Military Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제1호

발행연도: 2014.1

수록면: 239 - 244 (6page)

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Several recent studies have showed that the n-myc downstream regulated gene 2 (NDRG2) is a new tumor suppressor gene, and that it plays an important role in tumor suppression in several cancers or cancer cell lines. However, few studies focused on its function in neuroblastoma cells. In the present investigation, we demonstrated that NDRG2 overexpression inhibited their proliferation. Using a cDNA microarray, we found that overexpression of NDRG2 inhibited the expression of cysteine-rich protein 61 (CYR61), a proliferation related gene. From our research, CYR61 may partially hinder NDRG2-mediated inhibition of cell proliferation. Overexpression of NDRG2 resulted in accumulation of cells in the G1 phase, which was accompanied by upregulation of p21 and p27 and downregulation of CDK4 and cyclin D1. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of CYR61. Our findings offer novel insights into the physiological roles of NDRG2 in neuroblastoma cell proliferation, and NDRG2 may prove to be effective candidate for the treatment of children with neuroblastoma.

#NDRG2 #CYR61 #neuroblastoma #proliferation

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