Long Term Outcomes of Patients with Endometrial Carcinoma Treated with Radiation - Siriraj Hospital Experience

Setakornnukul, Jiraporn; Petsuksiri, Janjira; Wanglikitkoon, Sirentra; Warnnissorn, Malee; Thephamongkhol, Kullathorn; Chansilp, Yaowalak; Veerasarn, Vutisiri

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자료유형: 학술저널

저자정보: Setakornnukul, Jiraporn (Division of Radiation Oncology, Siriraj Hospital, Faculty of Medicine, Mahidol University) Petsuksiri, Janjira (Division of Radiation Oncology, Siriraj Hospital, Faculty of Medicine, Mahidol University) Wanglikitkoon, Sirentra (Udon Thani Cancer Hospital) Warnnissorn, Malee (Department of Pathology, Siriraj Hospital, Faculty of Medicine, Mahidol University) Thephamongkhol, Kullathorn (Division of Radiation Oncology, Siriraj Hospital, Faculty of Medicine, Mahidol University) Chansilp, Yaowalak (Division of Radiation Oncology, Siriraj Hospital, Faculty of Medicine, Mahidol University) Veerasarn, Vutisiri (Division of Radiation Oncology, Siriraj Hospital, Faculty of Medicine, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제5호

발행연도: 2014.1

수록면: 2,279 - 2,285 (7page)

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Background: To evaluate treatment outcomes of patients with stage I-III endometrial cancer treated with postoperative radiation. Materials and Methods: A retrospective review of 166 endometrial cancer patients, undergoing surgery and postoperative radiotherapy at Siriraj Hospital from 2005-2008 was performed. Pathology was reviewed. Results of treatment were reported with 5-year loco-regional recurrence free survival (LRRFS), 5-year overall survival (OS), patterns of failure and toxicity, and according to stage and risk groups. Results: Median follow up time was 62.8 months. Pathological changes were found in 36.3% of the patients after central reviews, leading to 19% changes in risk groups. Most of the patients (83.7%) received pelvic radiation (PRT) and vaginal brachytherapy (VBT). Five-year LRRFS and OS of all patients were 94.9% and 85.5%, respectively. There was no recurrence or death in low and low-intermediate risk groups. For the high-intermediate risk group, 5-year LRRFS and OS were 96.2% and 90.8%, respectively, and for the high risk group 90.5% and 71%. Late grade 3 and 5 gastrointestinal toxicity was found in 3% and 1.2% of patients, respectively. All of them received PRT 5,000 cGy in 25 fractions. Conclusions: Low and intermediate risk patients had good results with surgery and adjuvant radiation therapy. For high risk patients, postoperative radiation therapy alone appeared to be inadequate as the most common pattern of failure was distant metastasis.

#Endometrial carcinoma #radiation therapy #survival #central pathological review #FIGO 2009

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