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논문 기본 정보

자료유형
학술저널
저자정보
Chen, Xin-Ping (College of Agriculture, Hainan University) Xu, Wei-Hua (Department of Central Laboratory, the First Affiliated Hospital of Fujian Medical University) Xu, Da-Feng (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Fujian Medical University) Xie, Xian-He (Department of Chermotherapy, the First Affiliated Hospital of Fujian Medical University) Yao, Jia (Department of Breast Surgery, Hainan Province People's Hospital) Fu, Sheng-Miao (Department of Central Laboratory, the First Affiliated Hospital of Fujian Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제18호
발행연도
2014.1
수록면
7,741 - 7,746 (6page)

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Although a number of studies have been conducted on the association between GSTM1 polymorphisms and lung cancer in China, this association remains elusive and controversial. To clarify the effects of GSTM1 polymorphisms on the risk of lung cancer, a meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to 5th April 2014. A total of 45 articles (47 studies) including 6,623 cases and 7,865 controls were involved in this meta-analysis. Overall, a significant association (OR = 1.45, 95%CI: 1.32-1.60) was found between the null GSTM1 and lung cancer risk when all studies in Chinese population pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area and source of controls, the same results were observed under all the models. This meta-analysis showed that the null GSTM1 may be a potential biomarker for lung cancer risk in Chinese, but further studies with gene-gene and gene-environment interactions are required for definite conclusions.

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