Survey of HER2-neu Expression in Colonic Adenocarcinoma in the West of Iran

Madani, Seyed-Hamid; Sadeghi, Edris; Rezaee, Akram; Sadeghi, Masoud; Khazaee, Sedigheh; Amirifard, Nasrin; Payandeh, Mehrdad

추천

검색

자료유형: 학술저널

저자정보: Madani, Seyed-Hamid (Molecular Pathology Research Center, Imam Reza Hospital) Sadeghi, Edris (Cancer Research Center, Kermanshah University of Medical Sciences) Rezaee, Akram (Molecular Pathology Research Center, Imam Reza Hospital) Sadeghi, Masoud (Medical Biology Research Center, Kermanshah University of Medical Sciences) Khazaee, Sedigheh (Molecular Pathology Research Center, Imam Reza Hospital) Amirifard, Nasrin (Cancer Research Center, Kermanshah University of Medical Sciences) Payandeh, Mehrdad (Medical Biology Research Center, Kermanshah University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제17호

발행연도: 2015.1

수록면: 7,671 - 7,674 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Overexpression of HER2-neu has been reported in many epithelial malignancies, including cancers of the breast, ovaries, lungs, prostate, bladder, pancreas, colorectum and stomach as well as osteosarcomas. The aim of this study was evaluation of expression of HER2-neu immunohistochemistry (IHC) status and clinicopathologic features in a series of colonic adenocarcinomas. Materials and Methods: In this descriptive and analytical study, we surveyed 211 samples of colon adenocarcinoma from 182 patients (86.3%) undergoing total or partial colectomy and 29 (7.13%) with biopsies by colonoscopy. A sufficient sample size was obtained from all cases and the slides were stained with hematoxylin and eosin and also by IHC (HER2) staining. Results: The mean age for the patients at diagnosis was 57.9 years (range, 15-88 years). One hundred and twenty one patients (57.3%) were male. Of all patients, 201 samples (95.3%) were conventional adenocarcinomas (159, 29 and 13 cases were well, moderately and poorly differentiated, respectively) and 10 (4.7%) were mucinous type. Out of 211 cases, 171 were checked for lymph nodes metastasis and 64 were positive. There is a correlation between HER2 scores and differentiation, most score 3 cases being well differentiated (P<0.05). Conclusions: In patients with advanced colon cancer, surgery alone is not curative and other forms of therapy may be required to prolong patient survival. HER2 overexpression was found in some cases and this could be a guideline to new adjuvant therapy for these patients.

#Colon cancer #Her2-neu #IHC #differentiation #Iran

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Madani, Seyed-Hamid

소속기관 Medical Biology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences