HPV-Associated p16<sup>INK4A</sup> Expression and Response to Therapy and Survival in Selected Head and Neck Cancers

Kanyilmaz, Gul; Ekinci, Ozgur; Muge, Akmansu; Celik, Sevinc; Ozturk, Furkan

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자료유형: 학술저널

저자정보: Kanyilmaz, Gul (Department of Radiation Oncology, Faculty of Medicine, Necmettin Erbakan University) Ekinci, Ozgur (Department of Pathology, Faculty of Medicine, Gazi University) Muge, Akmansu (Department of Radiation Oncology, Faculty of Medicine, Gazi University) Celik, Sevinc (Department of Pathology, Faculty of Medicine, Corum Hitit University) Ozturk, Furkan (Department of Radiation Oncology Van Education and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제1호

발행연도: 2015.1

수록면: 253 - 258 (6page)

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Background: Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus (HPV) infection, which in turn is closely related with expression of $p16^{INK4A}$. Loss of $p16^{INK4A}$ expression by deletion, mutation, or hypermethylation is common in SCCHN. We here evaluated $p16^{INK4A}$ as a prognostic marker of treatment response and survival in our SCCHN patients with laryngeal, hypopharyngeal or nasopharyngeal cancers. Materials and Methods: 131 patients diagnosed with SCCHN between January 2,2006 and July 17, 2010 were examined for $p16^{INK4A}$. The median age was 60 years (15-82 years). Fifty one patients were stage I-II and 80 were stage III-IV. Immunohistochemical expression of $p16^{INK4A}$ was analyzed in pretreatment paraffin-embedded tumor blocks. The influence of $p16^{INK4A}$ status on disease-free survival, and overall survival after treatment was evaluated. Results: $p16^{INK4A}$ positivity was found in 58 patients (44%). Tumor-positivity for$ p16^{INK4A}$ was correlated with improved disease free survival (70.1 months vs 59 months) and improved overall survival (2, 3 and 5-year values; 77% vs 72%, 70% vs 63% and, 63% vs 55%; respectively). On multivariate analysis, stage was determined as independent prognostic factor for disease-free survival. Conclusions: Stage was the major prognostic factor on treatment response and survival in our patients. $p16^{INK4A}$ status predicts better outcome in laryngeal, hypopharyngeal or nasopharyngeal cancer cases treated with surgery plus adjuvant radiochemotherapy as well as with definitive radiation therapy and/or chemotherapy.

#p16 INK4Aa #hpv #head and neck cancer #radiotherapy #outcome

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