Lack of Association of Glutathione S-transferase M3 Gene Polymorphism with the Susceptibility of Lung Cancer

Feng, Xu; Dong, Chun-Qiang; Shi, Jun-Jie; Zhou, Hua-Fu; He, Wei; Zheng, Bao-Shi

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자료유형: 학술저널

저자정보: Feng, Xu (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) Dong, Chun-Qiang (Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University) Shi, Jun-Jie (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) Zhou, Hua-Fu (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) He, Wei (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) Zheng, Bao-Shi (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,465 - 4,468 (4page)

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Objective: The conclusions of published reports on the relationship between the glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung cancer are still debated. This meta-analysis was performed to evaluate the association between GSTM3 and the risk of lung cancer. Methods: Association investigations were identified from PubMed, Embase, and Cochrane Library, and eligible studies were included and synthesized using a meta-analysis method. Results: Eight reports were included into this meta-analysis for the association of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 patients with lung cancer and 1,926 controls. No association between the GSTM3 A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39). Conclusions: The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. However, more studies on the relationship between GSTM3 A/B gene polymorphism and the risk of lung cancer should be performed in the future.

#Lung cancer #glutathione S-transferase M3 #A/B gene polymorphism #meta-analysis

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Feng, Xu

소속기관 Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University