Relation of Serum Adiponectin Levels and Obesity with Breast Cancer: A Japanese Case-Control Study

Minatoya, Machiko; Kutomi, Goro; Shima, Hiroaki; Asakura, Sumiyo; Otokozawa, Seiko; Ohnishi, Hirofumi; Akasaka, Hiroshi; Miura, Tetsuji; Mori, Mitsuru; Hirata, Koichi

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자료유형: 학술저널

저자정보: Minatoya, Machiko (Department of Public Health, Sapporo Medical University School of Medicine) Kutomi, Goro (Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine) Shima, Hiroaki (Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine) Asakura, Sumiyo (Department of Public Health, Sapporo Medical University School of Medicine) Otokozawa, Seiko (Department of Public Health, Sapporo Medical University School of Medicine) Ohnishi, Hirofumi (Department of Public Health, Sapporo Medical University School of Medicine) Akasaka, Hiroshi (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) Miura, Tetsuji (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) Mori, Mitsuru (Department of Public Health, Sapporo Medical University School of Medicine) Hirata, Koichi (Department of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제19호

발행연도: 2014.1

수록면: 8,325 - 8,330 (6page)

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Background: It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk. Materials and Methods: We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status. Results: Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively). Conclusions: These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.

#Breast cancer #adiponectin #obesity #ethnicity #menopausal status #Japanese women

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