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자료유형
학술저널
저자정보
Wang, Wei-Jia (Department of Pathology, the First Affiliated Hospital of Nanchang University) Lei, Yuan-Yuan (Department of Pathology, the First Affiliated Hospital of Nanchang University) Mei, Jin-Hong (Department of Pathology, the First Affiliated Hospital of Nanchang University) Wang, Chun-Liang (Department of Neurosurgery, the First Affiliated Hospital of Nanchang University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제7호
발행연도
2015.1
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2,591 - 2,600 (10page)

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Breast cancer is the most common cancer worldwide among women and the second most common cancer. Approximately 15-23% of breast cancers over-express human epidermal growth factor receptor2 (HER2), a 185-kDa transmembrane tyrosine kinase, which is mainly found at the cell surface of tumor cells. HER2-positive breast cancer, featuring amplification of HER2/neu and negative expression of ER and PR, has the three following characteristics: rapid tumor growth, lower survival rate, and better response to adjuvant therapies. Clinically, it is notable for its role in a pathogenesis that is associated with increased disease recurrence and acts as a worse prognosis. At the same time, it represents a good target for anti-cancer immunotherapy despite the prevalence of drug resistance. New treatments are a major topic of research, and a brighter future can be expected. This review discusses the role of HER2 in breast cancer, therapeutic modalities available and prognostic factors.

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