Antitumor Activity of Chloroquine in Combination with Cisplatin in Human Gastric Cancer Xenografts

Zhang, Hui-Qing; Fang, Nian; Liu, Xiao-Mei; Xiong, Shu-Ping; Liao, Yu-Qian; Jin, Wen-Jian; Song, Rong-Feng; Wan, Yi-Ye

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자료유형: 학술저널

저자정보: Zhang, Hui-Qing (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital) Fang, Nian (Gastrointestinal Department of Internal Medicine, The Fourth Affiliated Hospital of Nanchang University) Liu, Xiao-Mei (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital) Xiong, Shu-Ping (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital) Liao, Yu-Qian (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital) Jin, Wen-Jian (Department of Geriatric Oncology, Jiangxi Provincial Cancer Hospital) Song, Rong-Feng (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital) Wan, Yi-Ye (The Third Department of Medical Oncology, Jiangxi Provincial Cancer Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제9호

발행연도: 2015.1

수록면: 3,907 - 3,912 (6page)

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Purpose: To investigate the antitumor activity and mechanism of chloroquine (CQ) in combination with cisplatin (DDP) in nude mice xenografted with gastric cancer SGC7901 cells. Materials and Methods: 35 cases of gastric cancer patients with malignant ascites were enrolled and intraperitoneal cisplatin injection was performed. Ascites were collected before and 5 days after perfusion for assessment of autophagy levels in cancer cells. In addition, 24 tumor-bearing mice were randomly divided into control, DDP, CQ and CQ + DDP groups. Results: In 54.3% (19/35) of patients the treatment was therapeutically effective (OR), 5 days after peritoneal chemotherapy, 13 patients had the decreased ascites Beclin-1 mRNA levels. In 16 patients who had NR, only 2 cases had decreased Beclin-1 (P=0.001). Compared with the control group, the xenograft growth in nude mice in the DDP group was low, and the inhibition rate was 47.6%. In combination with chloroquine, the inhibition rate increased to 84.7% (P<0.01). The LC3-II/I ratio, and Beclin1 and MDR1/P-gp expression were decreased, while caspase 3 protein levels increased (P<0.05). Conclusions: Antitumor ability of cisplatin was associated with autophagy activity and chloroquine can enhance chemosensitivity to cisplatin in gastric cancer xenografts nude mice.

#Cisplatin #chloroquine #gastric cancer #multi-drug resistance #xenografts

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