지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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PURPOSE: While electrical stimulation (ES) is known to be a safe and flexible tool in rehabilitation therapy, it has had limited adoption in muscle regeneration. This study was performed to investigate whether ES can induce myogenic differentiation and to clarify the mechanism underlying the effects of ES on myogenic differentiation. METHODS: This study used rat L6 cell lines as myoblasts for myogenic differentiation. Electric stimulation was applied to the cells using a C-Pace EP culture pacer (IonOptix, Westwood, Ma, USA). The gene expressions of myogenic markers were examined using qPCR and immunochemistry. RESULTS: Our study showed that ES increased the thickness and length of myotubes during myogenic differentiation. It was found that ES increased the expression of myogenic markers, such as MyoD and Myogenin, and also activated the fusion of the myoblast cells. In addition, ES suppressed the expression of small GTPases, which can explain why ES promotes myogenic differentiation. CONCLUSION: We found that ES induced myogenic differentiation by suppressing small GTPases, inhibiting cell division. We suggest that ES-based therapies can contribute to the development of safe and efficient muscle regeneration.
목차
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참고문헌 (32)
참고문헌 신청
Goodpaster BH / 2006 / The loss of skeletal muscle strength, mass, and quality in older adults : the health, aging and body composition study / J Gerontol A Biol Sci Med Sci 61(10):1059~1064
Faulkner JA / 2007 / Age-related changes in the structure and function of skeletal muscles / Clin Exp Pharmacol Physiol 34(11):1091~1096
Dolbow DR / 2016 / Effects of use and disuse on non-paralyzed and paralyzed skeletal muscles / Aging Dis 7(1):68~80
Sacco A / 2008 / Self-renewal and expansion of single transplanted muscle stem cells 456(7221):502
Loebel C / 2018 / Engineering stem and stromal cell therapies for musculoskeletal tissue repair / Cell Stem Cell 22(3):325~339
Faulkner JA / 2007 / Age-related changes in the structure and function of skeletal muscles / Clin Exp Pharmacol Physiol 34(11):1091~1096
Dolbow DR / 2016 / Effects of use and disuse on non-paralyzed and paralyzed skeletal muscles / Aging Dis 7(1):68~80
Sacco A / 2008 / Self-renewal and expansion of single transplanted muscle stem cells 456(7221):502
Loebel C / 2018 / Engineering stem and stromal cell therapies for musculoskeletal tissue repair / Cell Stem Cell 22(3):325~339
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