지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 47 - 51 (5page)
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초록· 키워드
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Inhibitory activities of the methanol extract from Triticum aestivum L. sprouts were examined against ${\alpha}$-amylase and ${\alpha}$-glucosidase. The active constituents of T. aestivum were isolated by chromatographic techniques and identified as ${\gamma}$-aminobutyric acid and ferulic acid on the basis of IR and NMR. ${\gamma}$-Aminobutyric acid and ferulic acid showed the high inhibitory activities with $IC_{50}$ values of $5.4{\pm}0.2$ and $9.5{\pm}0.1$ mM against ${\alpha}$-amylase, and $1.4{\pm}0.4$ and $4.9{\pm}0.3$ mM against ${\alpha}$-glucosidase. The methoxy group on the hydroxycinnamic acid of ferulic acid derivatives played important functions in the ${\alpha}$-amylase and ${\alpha}$-glucosidase inhibitory activities. Based on the $IC_{50}$ values of nitrite-scavenging activity, ferulic acid ($98{\pm}3.9{\mu}g/mL$) was the most effective constituent, followed by ${\gamma}$-aminobutyric acid ($182{\pm}4.2{mu}g/mL$), sinapic acid ($301{\pm}2.7{mu}g/mL$), and p-coumaric acid ($454{\pm}2.2{mu}g/mL$). These results indicate that ${\gamma}$-aminobutyric acid and ferulic acid could be useful as preventative agents, and possibly therapeutic modalities for the treatment of metabolic diseases.
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