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논문 기본 정보

자료유형
학술저널
저자정보
Jeong, Cheol (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Chung, Ho Yun (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Lim, Hyun Ju (Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine) Lee, Jeong Woo (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Choi, Kang Young (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Yang, Jung Dug (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Cho, Byung Chae (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Lim, Jeong Ok (Biomedical Research Institute, Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine) Yoo, James J. (Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine) Lee, Sang Jin (Wake Forest Institute for Regenerative Medi) Atala, Anthony J.
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제41권 제6호
발행연도
2014.1
수록면
661 - 667 (7page)

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Background Tissue expansion is an effective and valuable technique for the reconstruction of large skin lesions and scars. This study aimed to evaluate the applicability and safety of a newly designed skin expanding bioreactor system for maximizing the graft area and minimizing the donor site area. Methods A computer-controlled biaxial skin bioreactor system was used to expand skin in two directions while the culture media was changed daily. The aim was to achieve an expansion speed that enabled the skin to reach twice its original area in two weeks or less. Skin expansion and subsequent grafting were performed for 10 patients, and each patient was followed for 6 months postoperatively for clinical evaluation. Scar evaluation was performed through visual assessment and by using photos. Results The average skin expansion rate was $10.54%{\pm}6.25%$; take rate, $88.89%{\pm}11.39%$; and contraction rate, $4.2%{\pm}2.28%$ after 6 months. Evaluation of the donor and recipient sites by medical specialists resulted in an average score of 3.5 (out of a potential maximum of 5) at 3 months, and 3.9 at 6 months. The average score for patient satisfaction of the donor site was 6.2 (out of a potential maximum of 10), and an average score of 5.2 was noted for the recipient site. Histological examination performed before and after the skin expansion revealed an increase in porosity of the dermal layer. Conclusions This study confirmed the safety and applicability of the in vitro skin bioreactor, and further studies are needed to develop methods for increasing the skin expansion rate.
#Skin transplantation #Tissue expander devices #Cicatrix

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참고문헌 (4)

참고문헌 신청
Neumann CG. / 1957 / The expansion of an area of skin by progressive distention of a subcutaneous balloon; use of the method for securing skin for subtotal reconstruction of the ear / Plast Reconstr Surg (1946) 19:124~130 google schola Dotan L / 2009 / Pediatric tissue expansion: our experience with 103 expanded flap reconstructive procedures in 41 children / Isr Med Assoc J 11:474~479 google schola Ladd MR / 2009 / Bioreactor maintained living skin matrix / Tissue Eng Part A 15:861~868 google schola LoGiudice J / 2003 / Pediatric tissue expansion: indications and complications / J Craniofac Surg 14:866~872 google schola

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