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학술저널
저자정보
Jung, Bok Ki (Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) Lee, Won Jai (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) Kang, Eunhye (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) Ahn, Hyo Min (Department of Bioengineering, College of Engineering, Hanyang University) Kim, Yong Oock (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) Rah, Dong Kyun (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) Yun, Chae-Ok (Department of Bioengineering, College of Engineering, Hanyang University) Yun, In Sik (Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine)
저널정보
대한두개안면성형외과학회 Archives of craniofacial surgery : ACFS Archives of craniofacial surgery : ACFS 제18권 제1호
발행연도
2017.1
수록면
9 - 15 (7page)

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Background: Relaxin is a transforming growth factor ${\beta}1$ antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.

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