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논문 기본 정보

자료유형
학술저널
저자정보
(Dept. of Microbiology, Konyang University, Konyang University Hospital) (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea) (Dept. of Microbiology, Konyang University, Konyang University Hospital) (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea) (Biomedicine Research Group, Hanrib Life Tech, Bio 21 Center) (Biomedicine Research Group, Hanrib Life Tech, Bio 21 Center) (Dept. of Environmental Engineering, Jinju National University) (Dept. of Microbiology, Konyang University, Konyang University Hospital) (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea)
저널정보
한국조류학회(藻類) Algae Algae 제22권 제4호
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333 - 338 (6page)

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초록· 키워드

A fucoidan, isolated from Korean Undaria pinnatifida spoprophyll (UP-F), was investigated for its immunomodulating activity on murine macrophages and splenocytes, and its activity was compared with that of fucoidan from Fucus vesiculosus (FV-F). Treatment of UP-F resulted in inhibition of the growth of murine macrophage RAW 264.7 cells, but its cytotoxicity was not observed in normal murine splenocytes. FV-F was shown to be highly cytotoxic to both immune cells, and its cytotoxic activity was higher than that of UP-F. Treatment of UP-F induced TNF-α in a dose-dependent manner from two types of macrophages, RAW 264.7 cells and murine peritoneal macrophages. The TNF-α-inducing activity of UP-F was higher than that of FV-F. UP-F also actively induced chemokines (RANTES and MIP-1α) from RAW 264.7 cells. Furthermore, treatment of UP-F gave rise to activation of murine splenocytes to produce cytokine (IL-6) and chemokines (RANTES and MIP-1α), showing significantly higher activity than that of FV-F. These results indicate that UP-F is less cytotoxic to immune cells than FV-F, and possesses immunomodulating activity to produce cytokines and chemokines from macrophages and splenocytes.
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