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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Bae-Hwan (Department of Physiology, Brain Research Institute, Yonsei University College of Medicine) Chae, Youn-Byoung (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) Hwang, Hye-Jeong (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) Choi, Young-Kook (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) Hahm, Dae-Hyun (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) Han, Seung-Moo (Department of Biomedical Engineering, Kyung Hee University) Kang, Sung-Keel (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University) Lee, Hye-Jung (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) Pyun, Kwang-Ho (Department of Integrative Medicine, College of Medicine, Catholic University) Shim, In-Sop (Department of Integrative Medicine, College of Medicine, Catholic University of Korea)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제6권 제4호
발행연도
2006.1
수록면
324 - 329 (6page)

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Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.

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