지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 28 - 34 (7page)
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초록· 키워드
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Objectives: This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyperactivity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenerational transmission of maternal ACEs.
Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis.
Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p＜0.001) and antepartum health risks (p＜0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060–1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036–1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother’s ACE score affected the offspring’s ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011–0.124).
Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring’s brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.
Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis.
Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p＜0.001) and antepartum health risks (p＜0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060–1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036–1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother’s ACE score affected the offspring’s ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011–0.124).
Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring’s brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Sinai C / 2014 / Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder / Eur J Psychotraumatol 5:23911
Fagundes CP / 2013 / Stressful early life experiences and immune dysregulation across the lifespan / Brain Behav Immun 27:8~12
Hughes K / 2017 / The effect of multiple adverse childhood experiences on health : a systematic review and meta-analysis / Lancet Public Health 2:e356~e366
Bellis MA / 2015 / Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey / J Public Health(Oxf) 37:445~454
Madigan S / 2017 / Maternal adverse childhood experience and infant health : biomedical and psychosocial risks as intermediary mechanisms / J Pediatr 187:282~289.e1
Fagundes CP / 2013 / Stressful early life experiences and immune dysregulation across the lifespan / Brain Behav Immun 27:8~12
Hughes K / 2017 / The effect of multiple adverse childhood experiences on health : a systematic review and meta-analysis / Lancet Public Health 2:e356~e366
Bellis MA / 2015 / Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey / J Public Health(Oxf) 37:445~454
Madigan S / 2017 / Maternal adverse childhood experience and infant health : biomedical and psychosocial risks as intermediary mechanisms / J Pediatr 187:282~289.e1
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UCI(KEPA) : I410-ECN-0101-2021-516-001469677