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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 87 - 87 (1page)
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Humanized mice engrafted human cells or tissues using Immunodeficient mice have become crucial animal models for the study of human diseases, especially in cancer research. Recently, NSG mouse (NOD-PrkdcnullIL2rgnull) is widely used in humanized mouse production, however, there are limitations such as immunological leakiness and low radiation tolerance. To overcome these limitations, peripheral blood mononuclear cell (PBMC) engraft humanized mice were generated using NOD-Rag2nullIL2rgnull (RID) mice. PBMC were intravenously injected each 6 weeks old female and male mice. Examining flow cytometry results, more than 30% Human CD45+ cells were observed in the female group from 3 weeks after PBMC administration, more than 28% Human CD45+ cells were observed in the male group from 5 weeks. Most of Human CD45+ cells were CD3+ T cells, and the ratio of CD4+ and CD8+ cells was variable. Human CD66b+ granulocytes were genera ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-528-001569529