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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 91 - 91 (1page)
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Bromochlorophene(BCP) is an effective toothpaste and has shown good properties in other ways including sterilization, and antibacterial activity. This study aimed to investigate the single and repeated dose 28-days oral toxicity of an BCP suspension in Sprague–Dawley (SD) rats. For the single-dose toxicity study, dose of 25, 80, 250, 700, 1,000 mg per kg of body weight (mg/kg b.w.) of BCP was given once orally to SD rats. Mortality and clinical signs were observed and recorded for the first 30 min after treatment, at 4h post-administration and then at least once daily for 14 days after administration. For the repeated dose 28-day toxicity study, the high dose was set as 1,000 mg/kg b.w. and the middle, middle-low, and low dose were set to 500 mg/kg, 250 mg/kg and 125 mg/kg, respectively. Clinical signs as well as body weight and food consumption were measured and recorded daily. Hematology and biochemistry parameters were examined. Gross pathologic and histopathologic examinations were performed on selected tissues from all animals. Bacterial reverse mutation assay, in vitro chromosomal aberration assay and in vivo micronucleus assay ... 전체 초록 보기
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