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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Intracellular adhesion molecule-1 (ICAM-1) belongs to the immunoglobulin-like superfamily of adhesion molecules that mediate cell adhesion to other cells, and ICAM-1 is involved in cancer progression and recurrence. Since the ICAM-1 is considered as one of the therapeutic target against bladder cancer, we examined whether sulforaphane, an aliphatic isothiocyanate, could inhibit ICAM-1 expression in bladder cancer T24 cells. Sulforaphane inhibited phorbol 12-myristate 13-acetate (PMA)-induced ICAM-1 expression at the mRNA and protein levels in human bladder cancer cells, as revealed by reverse transcriptase polymerase chain reaction and western blot analyses, respectively. Specific inhibitor studies have shown that the transcription factors, activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB), are involved in PMA-induced ICAM-1 expression. We found that sulforaphane inhibited the activation of both AP-1 and NF-κB induced by PMA in bladder cancer cells. Interestingly, we also found that sulforaphane abrogated PMA-induced THP-1 monocyte adhesion to bladder cancer cells. Collectively, our results provide experimental evidence that sulforaphane could serve as a new therapeutic candidate against bladder cancer.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
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Mitra AP / 2009 / Strategies for molecular expression profiling in bladder cancer / Cancer Metastasis Rev 28:317~326
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Sievert KD / 2009 / Economic aspects of bladder cancer : what are the benefits and costs / World J Urol 27:295~300
Witjes JA / 2014 / Clinical and cost effectiveness of hexaminolevulinateguided blue-light cystoscopy : evidence review and updated expert recommendations / Eur Urol 66:863~871
Mitra AP / 2009 / Strategies for molecular expression profiling in bladder cancer / Cancer Metastasis Rev 28:317~326
Besaratinia A / 2013 / Genotoxicity of tobacco smokederived aromatic amines and bladder cancer : current state of knowledge and future research directions / FASEB J 27:2090~2100
Sievert KD / 2009 / Economic aspects of bladder cancer : what are the benefits and costs / World J Urol 27:295~300
Witjes JA / 2014 / Clinical and cost effectiveness of hexaminolevulinateguided blue-light cystoscopy : evidence review and updated expert recommendations / Eur Urol 66:863~871
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UCI(KEPA) : I410-ECN-0101-2021-511-001652148