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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 188 - 188 (1page)
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Cancer cell-targeting imaging is prerequisite for diagnosis and therapy. Despite the recent advances in imaging technologies, identification of cancer cells using affinity-based ligands (peptides or aptamers) is often challenging, due to the limited brightness of fluorescence signal especially at low expression of target receptors. Herein, we propose a ligand-assisted enzyme-accelerated signal enhancement (LA-EASE) technology to image cancer cells, in which an aptamer or a peptide can be used as a cell-targeting ligand and polydopamine (PDA) as a signal amplifier. When biotinylated ligands are treated with their target cancer cells, the LA-EASE reaction is achieved by the sequential reaction of streptavidin-conjugated horseradish peroxidase (HRP) and HRP-accelerated dopamine oxidation, thus leading to ... 전체 초록 보기
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