지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 32 - 49 (18page)
이용수
초록· 키워드
오류제보하기
The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.
목차
ABSTRACT
GUT BARRIERS
INTESTINAL EPITHELIUM
INTERCELLULAR BARRIERS
REGENERATION OF GUT EPITHELIUM
GUT-BRAIN COMMUNICATION
IMPACT OF THE GUT BARRIER AND MICROBIOME IN BRAIN DISEASE
MANIPULATION OF BRAIN HEALTH BY THE GUTENVIRONMENT
CONCLUSION
REFERENCES
참고문헌 (85)
참고문헌 신청
Gribble FM / 2016 / Enteroendocrine cells : chemosensors in the intestinal epithelium / Annu Rev Physiol 78:277~299
김새해 / 2020 / Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems / Immune Network 20(6):1~19
Kangseok Seo / 2021 / The role of mucosal barriers in human gut health / Archives of Pharmacal Research 44(4):325~341
Chaithanya Chelakkot / 2018 / Mechanisms regulating intestinal barrier integrity and its pathological implications / Experimental and Molecular Medicine 50:1~9
Szakál DN / 2010 / Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease / Virchows Arch 456:245~250
김새해 / 2020 / Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems / Immune Network 20(6):1~19
Kangseok Seo / 2021 / The role of mucosal barriers in human gut health / Archives of Pharmacal Research 44(4):325~341
Chaithanya Chelakkot / 2018 / Mechanisms regulating intestinal barrier integrity and its pathological implications / Experimental and Molecular Medicine 50:1~9
Szakál DN / 2010 / Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease / Virchows Arch 456:245~250
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