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(Yantai Yuhuangding Hospital) (Jeonbuk National University Medical School) (Jeonbuk National University Medical School) (Jeonbuk National University Medical School) (Korea Food Research Institute) (Yantai Yuhuangding Hospital) (Yantai Yuhuangding Hospital)
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대한체질인류학회 해부·생물인류학 해부·생물인류학 제34권 제2호
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    초록·키워드

    Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.

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      UCI(KEPA) : I410-ECN-0101-2021-511-001875289