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논문 기본 정보

자료유형
학술대회자료
저자정보
Jung-Hwan Kwon (Korea University)
저널정보
한국농약과학회 한국농약과학회 학술발표대회 논문집 2021년 한국농약과학회 정기총회 및 춘계학술발표회
발행연도
2021.5
수록면
15 - 21 (7page)

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Pyrethroids have been widely used as an active ingredient in home insecticide products since the 1960s. Although their occurrence in indoor environments has been studied, the contribution of home insecticide application to the aggregate exposure to pyrethroids is not well known. The objective of this study was to estimate the consumer exposure to permethrin, a representative pyrethroid, via the use of home insecticide spray during the summer season using biomonitoring, personal exposure monitoring and modeling. Exposure to permethrin was assessed both by measuring the time-weighted average air concentration using a low-volume air sampler and by analyzing its urinary metabolites, 3-phenoxybenzoic acid (3-PBA) and cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan carboxylic acid (cis/trans-DCCA), for a group of consumer volunteers (n = 31). For more than 50% of participants, the levels of metabolites increased significantly (p<0.05) with the application of home insecticide products, thereby suggesting that the heavy use of home insecticides during summer could be an important exposure route of permethrin in addition to other sources, such as food consumption. The total amount of excreted 3-PBA and cis/trans-DCCA was lower than the amount estimated by the exposure model for most participants, but the gap was partly filled when the personal air concentration was used instead of modeled concentration. The gap between modeled and monitored exposure concentration explains the amount lost after application, including sorption to and reaction with indoor surfaces and uncertainties in ventilation. The gap between the amount of metabolite excretion estimated based on measured concentration and biomonitoring is likely due to individual metabolic variations. These gaps provide margin of safety if the screening model is used for assessing the exposure to permethrin when it is used as an active ingredient for home insecticide products.

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