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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 51 - 51 (1page)
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Alzheimer's disease (AD) is the main cause of dementia characterized by a progressive impairment in cognitive function and brain pathologies including amyloid-β plaques and the adjacent neuroinflammation. Considering the role of reactive oxygen species (ROS)-triggered oxidative damages as a key upstream of AD pathology, dietary polyphenols, which are natural ROS-scavenger, and the polyphenol-rich medicinal mushrooms are receiving scientific attentions. Here, the water fraction of mixed mushroom mycelium, i.e., Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus, grown on solid barley medium was tested for the potential therapeutic effect against AD in vitro and in vivo. The thioflavin S fluorescence assay demonstrated that Zinc-induced increment of intracellular amyloid-beta (Aβ) aggregates were significantly inhibited in the PC-12 cells, a rat neuron-like cell line, treated with mixed mushroo ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-511-001942127