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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 315 - 327 (13page)
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초록· 키워드
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Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than a few years. New molecular understanding of the pathogenesis of pancreatic adenocarcinoma based on efforts led by The Cancer Genome Atlas and other groups has elucidated the landscape of this disease and started to produce therapeutic results, leading to the first introduction of targeted therapies for subsets of pancreatic cancers bearing specific molecular lesions such as BRCA mutations. These efforts have highlighted that subsets of pancreatic cancers are particularly sensitive to chemotherapy. The most common molecular lesions in pancreatic adenocarcinomas are mutations in an oncogene KRAS and the TP53 gene that encodes for tumor suppressor protein p53. This paper will review the landscape of pancreatic cancers, focusing on mutations of p53, a major tumor suppressor protein, in pancreatic cancers and possible therapeutic repercussions.
목차
INTRODUCTION
MUTATIONS OF p53 IN PANCREATIC CARCINOGENESIS:FROM PRECURSOR LESIONS TOINVASIVE CANCER
MUTATIONS OF p53 IN PANCREATIC CARCINOGENESIS:THE ROLE OF EPITHELIAL TO MESENCHYMAL TRANSITION AND PLURIPOTENCY IN PANCREATIC CANCER DISSEMINATION
PANCREATIC CANCERS WITHOUT KRAS OR TP53 MUTATIONS
TARGETING p53: THERAPEUTIC AVENUES IN PANCREATIC CANCER
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2021-514-001920657