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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 221 - 221 (1page)
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초록· 키워드
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In preclinical hepatotoxicity testing cell based are frequently relevant. However, prediction of drug induced liver injury remains a major challenge. Here we addressed the usefulness of frequently relevant markers of hepatocellular injury in human hepatocarcinoma cell line (HepG2) in response to treatment with either acetaminophen, amiodarone, etoposide, orphenadrine and/or lovastatin. The change in the cellular injury (AST, ALT and LDH) were determined toxicity and above drug concentrations as to evaluate the utility of these markers in vitro systems. Initially, treatment of HepG2 with any of the drugs caused a statistically significant reduction ... 전체 초록 보기
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