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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 611 - 621 (11page)
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초록· 키워드
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Bacterial endoribonuclease toxins belong to a protein family that inhibits bacterial growth by degrading mRNA or rRNA sequences. The toxin genes are organized in pairs with its cognate antitoxins in the chromosome and thus the activities of the toxins are antagonized by antitoxin proteins or RNAs during active translation. In response to a variety of cellular stresses, the endoribonuclease toxins appear to be released from antitoxin molecules via proteolytic cleavage of antitoxin proteins or preferential degradation of antitoxin RNAs and cleave a diverse range of mRNA or rRNA sequences in a sequence-specific or codon-specific manner, resulting in various biological phenomena such as antibiotic tolerance and persister cell formation. Given that substrate specificity of each endoribonuclease toxin is determined by its structure and the composition of active site residues, we summarize the biology, structure, and substrate specificity of the updated bacterial endoribonuclease toxins.
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참고문헌 (92)
참고문헌 신청
Nierlich DP / 1978 / Regulation of bacterial growth, RNA, and protein synthesis / Annu Rev Microbiol 32:393~432
Harms A / 2018 / Toxins, Targets, and Triggers : An overview of toxin-antitoxin biology / Mol Cell 70:768~784
Page R / 2016 / Toxin-antitoxin systems in bacterial growth arrest and persistence / Nat Chem Biol 12:208~214
Zhang Y / 2003 / MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli / Mol Cell 12:913~923
Pedersen K / 2003 / The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site / Cell 112:131~140
Harms A / 2018 / Toxins, Targets, and Triggers : An overview of toxin-antitoxin biology / Mol Cell 70:768~784
Page R / 2016 / Toxin-antitoxin systems in bacterial growth arrest and persistence / Nat Chem Biol 12:208~214
Zhang Y / 2003 / MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli / Mol Cell 12:913~923
Pedersen K / 2003 / The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site / Cell 112:131~140
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