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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제12호
- 발행연도
- 2020.1
- 수록면
- 1,819 - 1,826 (8page)
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Increasing evidence suggests a potential role of microbial colonization in the inception of chronic airway diseases. However, it is not clear whether the lung and gut microbiome dysbiosis is coincidental or a result of mutual interaction. In this study, we investigated the airway microbiome in interleukin 13 (IL-13)-rich lung environment and related alterations of the gut microbiome. IL-13- overexpressing transgenic (TG) mice presented enhanced eosinophilic inflammatory responses and mucus production, together with airway hyperresponsiveness and subepithelial fibrosis. While bronchoalveolar lavage fluid and cecum samples obtained from 10-week-old IL-13 TG mice and their C57BL/6 wild-type (WT) littermates showed no significant differences in alpha diversity of lung and gut microbiome, they presented altered beta diversity in both lung and gut microbiota in the IL-13 TG mice compared to the WT mice. Lung-specific IL-13 overexpression also altered the composition of the gut as well as the lung microbiome. In particular, IL-13 TG mice showed an increased proportion of Proteobacteria and Cyanobacteria and a decreased amount of Bacteroidetes in the lungs, and depletion of Firmicutes and Proteobacteria in the gut. The patterns of polymicrobial interaction within the lung microbiota were different between WT and IL-13 TG mice. For instance, in IL-13 TG mice, lung Mesorhizobium significantly affected the alpha diversity of both lung and gut microbiomes. In summary, chronic asthma-like pathologic changes can alter the lung microbiota and affect the gut microbiome. These findings suggest that the lung-gut microbial axis might actually work in asthma.
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참고문헌 (44)
참고문헌 신청
Wenzel SE / 2012 / Asthma phenotypes : the evolution from clinical to molecular approaches / Nat. Med 18:716~725
Wynn TA / 2003 / IL-13 effector functions / Annu. Rev. Immunol 21:425~456
Ingram JL / 2012 / IL-13 in asthma and allergic disease : asthma phenotypes and targeted therapies / J. Allergy Clin. Immunol 130:829~842
Zhu Z / 1999 / Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production / J. Clin. Invest 103:779~788
Liu AH / 2015 / Revisiting the hygiene hypothesis for allergy and asthma / J. Allergy Clin. Immunol 136:860~865
Wynn TA / 2003 / IL-13 effector functions / Annu. Rev. Immunol 21:425~456
Ingram JL / 2012 / IL-13 in asthma and allergic disease : asthma phenotypes and targeted therapies / J. Allergy Clin. Immunol 130:829~842
Zhu Z / 1999 / Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production / J. Clin. Invest 103:779~788
Liu AH / 2015 / Revisiting the hygiene hypothesis for allergy and asthma / J. Allergy Clin. Immunol 136:860~865
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