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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 185 - 193 (9page)
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초록· 키워드
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The number of commercially approved gene-edited crops is gradually increasing, and in South Korea, it has led to intense investment in gene-edited crop development to increase international competitiveness. However, as with genetically modified crops, the safety of gene-edited crops regarding unexpected risks for humans and the environment is subject to an ongoing debate. In particular, unintentional “off-target effects” have become the center of controversy. In this review, we discuss typical plant characteristics (including somatic variation and ploidy), the extent of various off-target effects in genetically modified crops generated via horizontal transfer in nature, and the off-target effects in commercial genetically modified crops. We conclude that most off-target effects possibly occurring in gene-edited crops are not expected to be critically harmful to humans or the environment. Therefore, existing regulation for genetically modified crops should be enough for the risk assessment of gene-edited crops.
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참고문헌 (60)
참고문헌 신청
Agapito-Tenfen AZ / 2018 / Revisiting risk governance of GM plants: the need to consider new and emerging geneediting techniques / Front Plant Sci 9:1874~1890
Aoki S / 1994 / Sequence of the cellular T-DNA in the untransformed genome of Nicotiana glauca that is homologous to ORFs 13 and 14 of the Ri plasmid and analysis of its expression in genetic tumors of N. glauca x N. langsdorffii / Mol Gen Genet 243:706~710
Aoki S / 1999 / Horizontal gene transfer and mutation:ngrol genes in the genome of Nicotiana glauca / Proc Natl Acad Sci USA 96:13229~13234
Aoki S / 2004 / Resurrection of an ancestral gene: Functional and evolutionary analyses of the Ngrol genes transferred from Agrobacterium to Nicotiana / J Plant Res 117:329~337
Carroll D / 2016 / Regulate genome-edited products, not genome editing itself / Nat Biotechnol 34:477~479
Aoki S / 1994 / Sequence of the cellular T-DNA in the untransformed genome of Nicotiana glauca that is homologous to ORFs 13 and 14 of the Ri plasmid and analysis of its expression in genetic tumors of N. glauca x N. langsdorffii / Mol Gen Genet 243:706~710
Aoki S / 1999 / Horizontal gene transfer and mutation:ngrol genes in the genome of Nicotiana glauca / Proc Natl Acad Sci USA 96:13229~13234
Aoki S / 2004 / Resurrection of an ancestral gene: Functional and evolutionary analyses of the Ngrol genes transferred from Agrobacterium to Nicotiana / J Plant Res 117:329~337
Carroll D / 2016 / Regulate genome-edited products, not genome editing itself / Nat Biotechnol 34:477~479
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