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자료유형
학술저널
저자정보
Volkan Yeter (Ondokuzmayıs University Hospital) Nurullah Kocak (Department of Ophthalmology Ondokuz Mayıs University) Mehmet Tayfun Arslan2 (Department of Ophthalmology Kırklareli State Hospital) Elif Kilic Kan (Department of Endocrinology Ondokuz Mayıs University)
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제35권 제3호
발행연도
2021.1
수록면
198 - 206 (9page)

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Purpose: To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatoryparameters in patients with thyroid-associated ophthalmopathy (TAO). Methods: In this retrospective case-control study, the blood-count parameters and neutrophil-to-lymphocyte ratio (NLR),platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic immune-inflammatory index (SII), thyroidperoxidase antibody, and anti-thyroglobulin antibody were evaluated in 46 patients with TAO and 46 matched controls. Theassociations of the immunoinflammatory parameters with clinical outcomes were analyzed among TAO patients. Results: Significant differences were found in NLR, PLR, SII, and lymphocyte count between the controls and the TAO group (p< 0.05 for all). In logistic regression analysis, these inflammatory parameters did not have any prognostic effect on the clinicaloutcomes of the TAO (p > 0.05 for all). The patients, who needed systemic treatment due to any ocular involvement of TAOduring the follow-up period, had significantly lower platelet count (p = 0.001) and PLR (p = 0.02) at the time of initial diagnosiswhen compared to the no treatment-needed group of the TAO patients. The initial platelet count was significantly associatedwith the subsequent steroid need due to TAO during the follow-up period (β = -0.02, p = 0.03). Conclusions: NLR, PLR, and SII may serve as potential inflammatory markers in the identification of the TAO, although theyhave no evident prognostic significance in TAO. However, the relatively lower platelet count at initial diagnosis may be associatedwith the need for systemic therapy during the follow-up in patients with TAO.

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