지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 481 - 487 (7page)
이용수
초록· 키워드
오류제보하기
Background: Reports on metastatic or invasive infections by hypervirulent Klebsiella pneumoniae (hvKP) have increased recently. However, the effects of its virulence on clinical course and outcomes in pneumonia patients have rarely been addressed. We assessed and compared the clinical features of hvKp and classic K. pneumoniae (cKP) strains isolated from patients with pneumonia caused by K. pneumoniae. We also investigated the effects of virulence factors and the K. pneumoniae capsular serotypes K1 and K2 on mortality. Methods: In this retrospective study, we enrolled 91 patients diagnosed as having pneumonia caused by K. pneumoniae and obtained their demographic and clinical data from medical records. We evaluated genes for K1 and K2, antimicrobial susceptibility, and the virulence genes rmpA, iutA, entB, ybtS, kfu, mrkD, and allS. Strains that possessed rmpA and iutA were defined as hvKP (N=39), while the remaining were classified as cKP (N=52). Odds ratio (OR) for the risk factors associated with 30-day mortality was calculated using the binary logistic regression model. Results: The 30-day mortality in all patients was 23.1%; it was 17.9% (7/39) in the hvKP group and 26.9% (14/52) in the cKP group (P=0.315). Bacteremia (OR=38.1; 95% confidence interval [CI], 2.5?570.2), altered mental status (OR=8.8; 95% CI, 1.7?45.0), and respiratory rate >30 breaths/min (OR=4.8; 95% CI, 1.2?20.0) were independent risk factors for 30-day mortality in all patients. Conclusions: Our results suggest that hypervirulence determinants do not have a significant effect on 30-day mortality in patients with pneumonia caused by K. pneumoniae.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Martin RM / 2018 / Colonization, infection, and the accessory genome of Klebsiella pneumoniae / Front Cell Infect Microbiol 8:4
Song JH / 2008 / Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens / Int J Antimicrob Agents 31:107~114
Chawla R / 2008 / Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries / Am J Infect Control 36(S4):S93~S100
Liu YC / 1986 / Klebsiella pneumoniae liver abscess associated with septic endophthalmitis / Arch Intern Med 146:1913~1916
Lee CR / 2017 / Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms / Front Cell Infect Microbiol 7:483
Song JH / 2008 / Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogens / Int J Antimicrob Agents 31:107~114
Chawla R / 2008 / Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries / Am J Infect Control 36(S4):S93~S100
Liu YC / 1986 / Klebsiella pneumoniae liver abscess associated with septic endophthalmitis / Arch Intern Med 146:1913~1916
Lee CR / 2017 / Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms / Front Cell Infect Microbiol 7:483
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The first case of abdominal mycotic aneurysm caused by K1 hypervirulent Klebsiella pneumoniae in a healthy adult
Acute and Critical Care
2021 .11
-
Risk Factors for Mortality in Patients with Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae and Escherichia coli bacteremia
Infection and Chemotherapy
2021 .09
-
급성 호흡기 감염으로 입원한 소아 환자에서 Chlamydia pneumoniae의 임상 양상: Mycoplasma pneumoniae와의 비교
Allergy Asthma & Respiratory Diseases
2015 .01
-
Mycoplasma Pneumoniae -Associated Necrotizing Pneumonia in Children : a case-report
고신대학교 의과대학 학술지
2019 .01
-
소아 마이코플라스마 폐렴에서 호흡기 바이러스 중복감염의 임상적 특징
Allergy Asthma & Respiratory Diseases
2017 .01
-
Osteomyelitis Caused by Hypervirulent Klebsiella pneumoniae : The First Korean Case With Family Spread
Annals of Laboratory Medicine
2021 .01
-
Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea
Allergy, Asthma & Immunology Research
2017 .01
-
Negative regulation of Streptococcus pneumoniae infection by CHIP
한국실험동물학회 학술발표대회 논문집
2016 .08
-
The Distribution of Multidrug-resistant Microorganisms and Treatment Status of Hospital-acquired Pneumonia/Ventilator-associated Pneumonia in Adult Intensive Care Units: a Prospective Cohort Observational Study
Journal of Korean Medical Science
2021 .10
-
Comparison of the virulence of Streptococcus pneumoniae in ICR mouse stocks of three different origins
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Macrolide 불응성 마이코플라즈마 폐렴과 적혈구포식림프조직구증: 증례보고와 문헌고찰
대한소아응급의학회지
2020 .01
-
마이코플라즈마 폐렴에서 발생한 급성호흡곤란증후군 2예
Allergy Asthma & Respiratory Diseases
2017 .01
-
Comparison of the virulence of Streptococcus pneumoniae in ICR mouse stocks of three different origins
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Cooperative interactions between TLR2 and TLR4 in Murine Klebsiella pneumoniae infection
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Analysis of Klebsiella as a Prognostic Factor of Ocular Outcomes in Endogenous Endophthalmitis with Decision Tree Analysis
Infection and Chemotherapy
2018 .01
-
Escherichia coli와 Klebsiella pneumoniae 균혈증의 베타락탐 내성 추세와 세포탁심 감수성 ESBL 생성균주의 임상적 특징
의료관련감염관리
2023 .06
-
Devastating Community-Acquired Bacterial Meningitis Caused by Hypervirulent Klebsiella pneumoniae in an Immunocompetent Patient
Journal of Clinical Neurology
2021 .01
-
Risk of Klebsiella pneumoniae Endogenous Endophthalmitis during Bacteremia: Implications for Screening
Infection and Chemotherapy
2021 .01
-
Comparison of Escherichia coli and Klebsiella pneumoniae Acute Pyelonephritis in Korean Patients
Infection and Chemotherapy
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0