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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제1호
- 발행연도
- 2021.1
- 수록면
- 145 - 154 (10page)
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초록· 키워드
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Objective: Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present in the etiology of ADHD. This study aims to investigate the possible role of visfatin, IL-6, IL-1? and TNF-? molecules in the etiology of ADHD. Methods: The study included 60 patients and 20 healthy controls between the ages of 6?18. Serum visfatin, IL-6, IL-1? and TNF-? levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at a biochemistry laboratory. Results: The study showed no statistically significant difference between children with ADHD and healthy controls in terms of visfatin, IL-6, IL-1? and TNF-? levels. When ADHD subgroups (combined and predominantly inattentive types) and the control group were compared in terms of visfatin, IL-6, IL-1? and TNF-? levels, no statistically significant difference was recorded. Conclusion: Data on the relationship between ADHD and IL-6, IL-1? and TNF-? in this study are in compliance with the literature. However, no study was found on visfatin in ADHD. This study is the first one evaluating the ADHD-Visfatin relationship.
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참고문헌 (32)
참고문헌 신청
Faraone SV / 2005 / Molecular genetics of attention-defi-cit/hyperactivity disorder / Biol Psychiatry 57:1313~1323
Percinel I / 2015 / Iron deficiency in the pathophysiology of attention deficit hyperactivity disorder / Current Approaches to Psychiatry 7:41~55
Leffa DT / 2018 / A review on the role of inflammation in attention-deficit/hyperactivity disorder / Neuroimmunomodulation 25:328~333
Anand D / 2017 / Attentiondeficit/hyperactivity disorder and inflammation : what does current knowledge tell us? A systematic review / Front Psychiatry 8:228
Segman RH / 2002 / Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder / Mol Psychiatry 7:72~74
Percinel I / 2015 / Iron deficiency in the pathophysiology of attention deficit hyperactivity disorder / Current Approaches to Psychiatry 7:41~55
Leffa DT / 2018 / A review on the role of inflammation in attention-deficit/hyperactivity disorder / Neuroimmunomodulation 25:328~333
Anand D / 2017 / Attentiondeficit/hyperactivity disorder and inflammation : what does current knowledge tell us? A systematic review / Front Psychiatry 8:228
Segman RH / 2002 / Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder / Mol Psychiatry 7:72~74
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